L-arginine:glycine amidinotransferase (AGAT; EC: 2.1.4.1) and its metabolites homoarginine (hArg) and creatine play an important role in cardiovascular disease (CVD) such as myocardial infarction (MI), heart failure (HF) and ischemic stroke1–5. This evidence concerns the gene GATM and myocardial infarction.