PDE1C and hypertensive disorder: For seven of overall 17 potential target genes, we found studies reporting a role in CVD, comprising HF and cardiac remodeling after MI (Ccnd2, Pde1c, Ddah1), atherosclerosis (Igf1r), blood pressure and hypertension (Fign, Efnb3), and type 2 diabetes (Igf2bp2).