The association of APOE E2 and E4 carriers with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) did not change considerably after adjusting for smoking status, alcohol consumption, sedentary lifestyle, hypertension, type 2 diabetes, LDL and HDL cholesterol. Here, APOE is linked to type 2 diabetes mellitus.