When compared with E3 homozygotes, both APOE E2 and APOE E4 carriers showed no significant association with incident MI (E2 HR: 1.07 [95% CI 0.74, 1.56]; E4 HR: 1.03 [95% CI 0.76, 1.40]) and incident stroke (E2 HR: 0.70 [95% CI 0.44, 1.09]; E4 HR: 0.93 [95% CI 0.67, 1.30]) even in the age- and sex-adjusted model. Here, APOE is linked to Stroke.