For instance, the signaling pathways VEGF (bonferroni correction, p = 4.76e−17), PDGF (p = 8.81e−16), and FGF (p = 2.94e−18) all showed a higher activity (high flux) on tumor-side (Fig. 5A; Supplement Fig. 4), which potentially reflects a sustained angiogenesis39,40. The gene discussed is VEGFA; the disease is neoplasm.