GPFA showed that signaling pathways mTor (bonferroni correction, p = 0.02), HIF (p = 0.02), FOXO (p = 0.01), PI3K-AKT (p = 0.04), integrin (p = 0.04), JAK-STAT (p = 0.01) and others displayed a higher flux in the adenocarcinoma sub-group compared to the squamous cell carcinoma group (Fig. 4D,F). This evidence concerns the gene AKT1 and squamous cell carcinoma.