NLRP3 and Parkinson disease: However, if FYN upstream is affected such that both NLRP3 and Kv1.3 signaling are enhanced simultaneously, particularly together with Nf-κB, given its known role in upregulating NLRP3 and Kv1.3 expression, and other potassium channels, these genes if present in some combination may form a polygenic risk panel for PD pathology proceeding according to our hypothesis that could be identified upon genetic screening.