Previous work by our group documented the ability of dopamine to block not only canonical and noncanonical but also α-syn-induced NLRP3 inflammasome-mediated IL-1β secretion from isolated primary human microglia, and DRD1 agonism in both primary human microglia and in vivo in the SYN120 transgenic parkinsonism model decreased microglial inflammasome activation (Pike et al., in press). The gene discussed is NLRP3; the disease is Parkinson disease.