While microglial production of other, non-inflammasome-related cytokines is also attenuated by Kv1.3 blockade106, we suggest that the K+ efflux aspect of NLRP3 inflammasome activation may account in part for the deleterious role of microglial Kv1.3 in PD-associated neurodegeneration and neuroinflammation. This evidence concerns the gene NLRP3 and Parkinson disease.