Since the MPTP, α-synPFF, and MitoPark parkinsonism models as well as LPS treatment of microglia are all associated with both enhanced Kv1.3 expression100,102–105 and augmented NLRP3 inflammasome activation14,67,83, the question arises as to whether there may be a direct link between Kv1.3 activity and inflammasome activation. This evidence concerns the gene NLRP3 and Parkinson disease.