If the dopamine countersignal thus fades, the extent of microglial inflammasome activation could overtake that of dopamine-mediated inhibition, escaping regulation to a point of imbalance and a net amplification of NLRP3 inflammasome- and Kv1.3-associated PD pathology, with the dopaminergic neurons becoming overwhelmed and succumbing to the microglia. Here, NLRP3 is linked to Parkinson disease.