If both of these tests are abnormal, and cancer is ruled out through analysis of the original blood sample or other appropriate methods (as Kv1.3 expression can be associated with some cancers142 and abnormal 18F-DOPA PET results can be indicative of neuroendocrine tumors143), the combination could be indicative of prodromal PD and intervention could be possible prior to large scale neurodegeneration and the development of motor symptoms. The gene discussed is KCNA3; the disease is Parkinson disease.