We examined the overlay of human lung adenocarcinoma gene signatures with murine gene expression from invasive (Tgfbr2−/−) and non-invasive (Tgfbr2wt) tumors and show that the pro-invasive and indolence signatures classify tumors from 11 mice into two groups (Methods) that exactly match their Tgfbr2 status (Fig. 1e). The gene discussed is TGFBR2; the disease is lung adenocarcinoma.