Using a genetically engineered mouse model, we previously reported Tgfbr2 as a determinant of invasive phenotype of esLUAD, likely through modulating the tumor microenvironment that was enriched for expression of genes in the COL1A2 subnetwork and not for genes in the TPX2/AURKB signaling subnetwork35. Here, TGFBR2 is linked to neoplasm.