In the human LUAD dataset, TGFBR2 is included in the indolence signature and the indolence signature genes are significantly enriched for genes involved in the TGFB pathway (Supplementary Data 2), confirming the importance of TGFBR2 in tumor invasion and providing a potential model for assessing tumor cell aurora kinase signaling impact on the tumor microenvironment. The gene discussed is TGFB1; the disease is neoplasm.