Multiplex immunohistochemistry (Fig. 3D–G) showed that in the cortex of COVID-19 patients CD4 positive T-cells (Fig. 3D, H) were more numerous than in influenza patients (mean number/HPF 17.5 ± 3.3 versus 9.2 ± 1.9; p < 0.0001) and CD8 positive T-cells (Fig. 3E, I) were more numerous in COVID-19 patients as well (mean number/HPF 6.3 ± 1.6 versus 2.0 ± 1; p < 0.0001). This evidence concerns the gene CD8A and influenza.