Besides, the overexpression of HMGB3 significantly reduced the protein levels of cleaved caspase 3 and cleaved PARP1 following olaparib treatment, whereas ovarian cancer cells with HMGB3 knockdown showed increased levels of cleaved caspase 3 and cleaved PARP1 (Fig. 3A–D). Here, CASP3 is linked to ovarian carcinoma.