CXCR4 and hereditary elliptocytosis: Although a comparable role for CXCL12/CXCR4 interactions during HSC formation from HE in the mammalian AGM has not yet been established to our knowledge, studies using murine and human pluripotent stem cells have demonstrated that CXCR4 is a marker of arterial HE enriched in lymphoid potential in vitro93, and that CXCL12 can promote multilineage hematopoietic output downstream of the hemangioblast stage94 and negatively regulate the endothelial potential of CXCR4-expressing HE95.