Furthermore, degradation of protein phosphatase 3 catalytic subunit alpha (PPP3CA), the catalytic subunit of calcineurin, may suppress tumor growth and metastasis, further supporting the role of the NFAT signaling pathway in carcinogenesis [15], although additional functional studies are required to understand the functions of NAFTc4 and PPP3CA in colorectal cancer. This evidence concerns the gene PPP3CA and neoplasm.