To assess the effect of NFATc4 in oxaliplatin resistance in colorectal cancer, we constructed CAMTA1 overexpression, NFATc4 overexpression, and CAMTA1 + NFATc4 overexpression cells in SW620 cells, CAMTA1 knockdown, NFATc4 knockdown, and CAMTA1 + NFATc4 knockdown cells in sw480 cells (i.e., for SW480 cells, CAMTA1-OE, CAMTA1-OE + NFATc4-OE, NFATc4-OE; for SW620 cells, CAMTA1-siRNA, CAMTA1-siRNA+NFATc4-siRNA, NFATc4-siRNA). The gene discussed is NFATC4; the disease is colorectal cancer.