Nuclear factor of activated T cells, cytoplasmic 4 (NFATc4) is a member of another transcription factor family, the NFAT family, whose activation is regulated by calcineurin, a Ca++- and calmodulin-dependent serine/threonine protein phosphatase, and its role in a variety of cancers has been established [12–14]. Here, NFATC4 is linked to cancer.