For instance, DLL1 governs cell differentiation and cell-to-cell communication54, DLL3 suppresses cell growth by inducing apoptosis55, DLL4 activates NF-κΒ signaling to enhance vascular endothelial factor (VEGF) secretion and tumor metastasis56, JAG1 enhances angiogenesis54, and JAG2 promotes cell survival and proliferation54. Here, JAG2 is linked to neoplasm.