Remarkably, the anti-tumor effects of CD8+ T cells were abrogated specifically in mPTC/Tbx3−/− with recovered tumor growth, since cytotoxic CD8+ T cell were significantly depleted compared to anti-IgG in mPTC/Tbx3−/− (Fig. 6g and Supplementary Fig. 6i). This evidence concerns the gene TBX3 and neoplasm.