CDKN2A and glioblastoma: CDKN2A is a prominent tumor suppressor gene, frequently affected by homozygous deletions (HD) in IDHmut GBM [8], Therefore we tested the methylation of the CpG-probe cg07562918 (M-value) located in the CDKN2A gene that was significantly associated with age acceleration and tumor classification, for association with the HD-status.