MLLT10 and myeloid leukemia: Structural and functional analyses have shown that there is a conserved binding mode between the coiled-coil domains of DOT1L and the octapeptide motif-leucine-zipper (OM-LZ) region of AF10 (AF10OM−LZ), which has been confirmed to be essential for both MLL-AF10- and clathrin assembly lymphoid myeloid leukemia (CALM)-AF10-induced leukemogenesis (Fig. 6c) [11, 50, 51].