Acute leukemias in which the mixed lineage leukemia (MLL, also called MLL1 or KMT2A) gene is translocated at 11q23 accounts for approximately 35–50% of pediatric acute myeloid leukemia (AML) and up to 80% of acute lymphocytic leukemia (ALL). This evidence concerns the gene KMT2A and acute myeloid leukemia.