Although most changes in DNA methylation did not occur at direct FOXA1 and GATA3 binding sites, which might result from indirect effects, we did observe a gain of DNA methylation at direct FOXA1 or GATA3 binding sites showing that FOXA1 and GATA3 do maintain hypo-methylated regions at a subset of their binding sites in cancer cells. Here, GATA3 is linked to cancer.