Our approach recapitulated several of the predictions from Yao et al. [13] such as the AP-1 family TFs (JUN/FOS) in several cancer types, FOXA1 and GATA3 in BRCA, NFE2L2 in LUSC, FOXA2, SOX17, and LEF1 in UCEC, and CEBPB, SPI1 and IRF7 in KIRC (Additional file 1: Figure S1 and S2). The gene discussed is SPI1; the disease is cancer.