Only very few hyper-methylated DMRs were identified as CpG-poor both distal and proximal and therefore only few TFs showed both motif enrichment and TF downregulation (Additional file 1: Figure S1): KLF5 in BRCA; FOXA2 in CHOL; ARID5B in KIRC; STAT3 in PRAD; RXRG, EGR2 and ZNF263 in UCEC. This evidence concerns the gene KLF5 and prostate adenocarcinoma.