While the anticancer effect of vitamin A-coupled lipid nanoparticle containing siRNA against Hsp47 is unclear, the PEGylated polyethylenimine-coated gold nanoparticles containing all-trans retinoic acid and siRNA against HSP47 could inhibit ECM deposition, enhance drug delivery to pancreatic tumors and improve chemotherapy efficacy [137]. The gene discussed is SERPINH1; the disease is pancreatic neoplasm.