PIEZO1 and experimental autoimmune encephalomyelitis: However, recent study in an animal model of experimental autoimmune encephalomyelitis demonstrates that Piezo1 deletion in T cells does not affect effector T cells function but paradoxically expand the pool of immunosuppressive regulatory T (Treg) cells, suggesting that activation of Piezo1 in T cells may enhance immune response in this autoimmune disease [125].