ECM stiffness-induced mechanical forces also down-regulate ubiquitin domain-containing protein 1 expression or redistribute ubiquitin domain-containing protein 1 to cell–cell contacts and prevent the association between the E3 ubiquitin ligase β-TrCP and YAP1, thereby suppressing YAP1 degradation and facilitating ROCK2-dependent YAP1 activation, EMT, cancer cells migration and invasion [89, 90]. This evidence concerns the gene YAP1 and cancer.