ADIPOQ and calcium oxalate urolithiasis: In the animal study of anti-urolithialic activity of Solanum nigrum, the fruit hydroalcoholic extract elicited potent activity against calcium oxalate urolithiasis effected by ethylene glycol through tumour necrosis factor adiponectin stimulation and alpha inhibition, also maintained the balance between stone promoter and inhibitor such as calcium and magnesium, respectively [214].