In addition, pretreatment of the NSCLC cells with NAC, a ROS scavenging agent, would rescue the CPX’s effects on the expressions of ATF4, PDI, BiP, CHOP and PDI, as well as the activation of both PERK and eIF2α (Fig. 5B). The gene discussed is EIF2AK3; the disease is non-small cell lung carcinoma.