SOCS3 and hepatocellular carcinoma: Furthermore, Ge et al. [32] found that miR-650 in benzo[a]pyrene-exposed cancer cells contributed to HCC metastasis by directly targeting suppressor of cytokine signalling 3 (SOCS3), and this inhibition modulated the activation of the Janus kinase (JAK)/ signal transducer and activator of transcription 3(STAT3) cascade.