METTL14 and neoplasm: Further study revealed that the METTL14-YTHDF2 axis maintained the balance between cytotoxic CD8+ T cells and dysfunctional T cells, and METTL14-depleted TAMs overexpressing Epstein-Barr virus-induced protein 3 (Ebi3) transcripts inhibited the anti-tumor activity of CD8+ T cells, which resulted in the conversion of CD8+ T cells to dysfunctional T cells.