ATG5 and non-small cell lung carcinoma: Liu et al. found that METTL3-mediated autophagy is involved in NSCLC resistance to gefitinib, and further mechanistic studies revealed that METTL3 in NSCLC regulates autophagy-related gene expression such as ATG5, ATG7, LC3B, and SQSTM1 to promote cell survival in an m6A manner [50].