We found that several tumor hallmarks were dynamically enriched in the cluster1 compared with cluster2, including cell cycle pathway (normalized enrichment score [NES] = 2.01, FDR q value = 0.006), citrate cycle (TCA cycle) pathway (NES = 2.18, FDR q value = 0.013), and P53 signaling pathway (NES = 1.91, FDR q value = 0.001) (Fig. 4D-F) [23–25]. Here, TP53 is linked to neoplasm.