BIRC5 and neoplasm: In most, but not all, tumor types, we observed a trend that patients in the high BIRC5 group were generally younger at initial pathological diagnosis, e.g. ESCA (mean age 64.21 in high BIRC5 group vs 78.50 in low BIRC5 group; P = 0.001), KIRP (61.21 vs 64.48 years; P = 0.01), LGG (42.31 vs 47.83 years; P = 0.01), PCPG (44.15 vs 54.05 years; P < 0.001).