After adjusting for both age and tumor grade, BIRC5 expression was found to have an adverse effect on OS in KIRC, LGG, LIHC, and PAAD (hazard ratio (HR) > 1, P < 0.05), whereas BIRC5 expression was associated with a protective effect in OV (HR = 0.86; 95% confidence interval (95% CI): 0.75–1.00; P = 0.047). Here, BIRC5 is linked to neoplasm.