NPPB and chronic kidney disease: Multivariable analysis including renal function patterns, persistence of congestion, BNP reduction ≥30% adjusted for age, gender, previous CHF, CKD, LVEF <50%, and CV risk factors confirmed the independent relation of TI [HR: 2.30 (1.52–3.50); p < 0.001], TW [HR:0.30 (0.17–0.55); p < 0.001], PW [HR: 1.51 (1.02–2.24); p = 0.04], persistence of congestion [HR: 1.87 (1.39–2.52); p < 0.001] and NTproBNP reduction≥30% [HR 0.65 (0.48–0.87); p = 0.004] with clinical outcome (Table 3).