Notably, increasing lines of evidence have shown that NGF can be crucial for the treatment of blinding diseases, such as retinal degenerations, and several studies have already described the protective effect of NGF administration in experimental models of retinitis pigmentosa (RP) (Rocco et al., 2015) and age-related macular degeneration (AMD) (Lambiase et al., 2009). The gene discussed is NGF; the disease is age-related macular degeneration.