In these studies, five HDAC6 inhibitors, potassium acetate (Lu et al., 2016), tubacin (de Zoeten et al., 2011), BML-281 (Do et al., 2017), LTB2 (Liu et al., 2017), and CKD-506 (Lee et al., 2020), could alleviate DSS-induced murine colitis by targeting microtubule disassembly, regulating the functions of Foxp3(+) T-regulatory cells, suppressing the infiltration of CD19(+) B cells into the inflamed colonic lamina propria, unknown mechanisms, or blocking NF-κB signaling, respectively. Here, HDAC6 is linked to colitis.