P2RX7 and hypertrophic cardiomyopathy: Aloss-of-function mutation in the P2RX7 gene (556C>A) hasbeen recently found to associate with hypertrophic cardiomyopathy in a family fromIndia,54 but anotherstudy found no association between two P2RX7 SNPs, the gain offunction 489C>T and the loss-of-function 1513A>C, and acute heartfailure in a geriatric population.55