In 2010, Jauregui-Osoro et al. [22] updated the isotope exchange radiolabeling of [18F]TFB and reported NIS-specific accumulation of [18F]TFB in a preclinical model of normal thyroid tissue and thyroid cancer, proving that TFB is an effective NIS-targeted physiological imaging agent. This evidence concerns the gene SLC5A5 and thyroid gland carcinoma.