ASH1L and Beta-thalassemia: ASH1L, a histone methyltransferase with H3K4 and H3K36 methyltransferase activity, also plays an important role in erythropoiesis, and has been implicated as a regulator of beta globin, with a point mutation in ASH1L associated with a beta thalassemia phenotype.(Breton et al., 2016).