Furthermore, apart from differentially expressed genes in BC, miRNA expression affects cell cycle progression, epithelial-mesenchymal transition, cytokine-cytokine receptor interactions, and downstream cancer pathways, including phosphatidylinositol 3-kinase (PI3K)-Akt signaling and mitogen-activated protein kinase signaling pathways (Lee et al., 2018). This evidence concerns the gene AKT1 and breast cancer.