Under the LASSO regression and multivariate Cox regression analysis, five lncRNAs(ZNF236-DT, CASC8, PAN3-AS1, SH3PXD2A-AS1, LINP1) of them were selected to establish the novel prognostic FRLS for predicting the OS of patients with pancreatic cancer. This evidence concerns the gene ZNF236 and pancreatic neoplasm.