CFTR and cystic fibrosis: For example, intron 8 TI would provide correction for 89.1% of the CF-causing CFTR alleles listed in the CFTR2 database including F508del, common PTCs (e.g. G542X, R785X, and W1282X), and splicing variants (e.g. 3,849 + 10 kb C > T) (Suzuki et al., 2020), whereas exon 1 (Vaidyanathan et al., 2021) or intron 1 targeting would provide correction for nearly all CFTR mutations.