CYBB and Hypertension: The NCF1 gene encodes for p47phox, the regulatory subunit of the NADPH oxidase (NOX) complexes NOX1 and NOX2, which generate ROS in the vessel walls, leading to hypertension.9 These clinical findings have been confirmed by Troia et al. in Eln+/− mice, shown to have elevated vascular ROS production, and Eln+/−; Ncf1+/− mice, whose arterial cells produce less ROS than those from Eln+/− animals.