The same was true after in vitro infection of BMDM with Listeria monocytogenes or following irradiation or treatment of BMDM with etoposide, establishing a wider role of ATM in regulating BMDM type I IFN responses at homeostasis (where no dsDNA breaks are detectable), infection or classical genotoxic stress induced by dsDNA breaks (i.e. irradiation or etoposide). The gene discussed is ATM; the disease is infection.