There is existing evidence that individuals with other forms of ichthyosis may exhibit contractures, thickening of the palmar fascia, and constricting bands of skin (Craiglow, 2013; Palmer and Louis, 1976), and acute inhibition of STS in mice has been associated with increased expression of the fibrosis-related genes Ccn2 (Ctgf) and Ccn3 (Nov) (Humby et al., 2016; Rebolledo et al., 2021). Here, CCN2 is linked to ichthyosis.