While data suggests that after natural infection of SARS-CoV-2, the development of anti-spike protein immunoglobulin M (IgM) and immunoglobulin G (IgG) occurs at approximately 10 days after the onset of symptoms, (6–9) the longevity of Abs mediated by adaptive immunity to SARS-CoV-2 has not been fully determined (10–13). Here, CD40LG is linked to infection.