Noteworthy amongst the examples are rs738409 (PNPLA3, associated with cirrhosis, risk in Pitta), rs11603334 (ARAP1, fasting blood proinsulin levels, risk in Kapha), rs1552224 (ARAP1, acute insulin response, risk in Vata) and rs682331 (NIBAN1, obesity related traits) in the Vadu cohort, and rs699 (AGT, mean arterial pressure, risk in Vata) and rs2792751 (GPAM, HDL cholesterol levels, Apolipoprotein A1 levels, risk in Pitta) in the NI cohort (Table 1). This evidence concerns the gene GPAM and obesity due to melanocortin 4 receptor deficiency.