The results of univariate Cox regression suggested that eight genes were associated with recurrence in PACA patients, they were MCOLN1, PKD1, TRPC7, TRPV4, MCOLN3, TRPM1, TRPM4, and TRPC3 (Supplementary Table S1). This evidence concerns the gene TRPM4 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.