Of note, the difference in TP53 mutation frequency between high- and low-expressing tumors of TRPC3 was not observed; however, this difference was very significant between the high and low groups of TRPC7 (p = 0.86 vs. p = 0.02, respectively) further calling for investigation of the biological function of TRPC7 in the context of an existing known prominent hallmark tumor mutation in TP53 gene. This evidence concerns the gene TP53 and neoplasm.