Hence, the purpose of this study was to examine if affective and CFS-like symptoms due to RA are associated with RA severity, autoimmune biomarkers (RF and anti-CCP), signs of immune activation (IL-6, CRP, GM-CSF, IL-10, soluble TLR4), and other biomarkers including CD17, FBXW7, and EOS biomarkers (β-endorphins, MOR, KOR, and endomorphin-2). This evidence concerns the gene IL6 and myalgic encephalomeyelitis/chronic fatigue syndrome.