We also stratified remarkable SNPs as molecular–biological markers in the diagnosis and prognosis of gastrointestinal carcinomas such as PIK3CA rs141178472, PAUF rs12373, CD44 rs13347, rs6504593, and rs1049109 in 3’ UTR of IGF2BP1, TGFBR1 rs1590, MLH3 rs108621, ERCC1 rs3212986, SMAD7 rs4939827, GREM1 rs12915554, KRAS rs74693964, IL-23R rs10889677, IL-17A rs3748067, MTMR3 rs12537, ERBB3 rs3202538, IRF-1 rs56288038, IL-1RN rs9005, IL-1F5 rs2472188 and rs2515401, SCRN1 rs6976789. The gene discussed is ZG16B; the disease is digestive system carcinoma.