Regarding the smoking status, the analysis revealed a moderate positive correlation between former smokers and altered PIK3CA and (r = 0.364698; p = 0.0401), and a moderate negative correlation between never smokers and altered PIK3CA (r = −0.3647; p = 0.0401); a moderate negative correlation between former smokers and adenocarcinoma (r = −0.30949; p = 0.013); and a moderate positive correlation between never smokers and adenocarcinoma (r = 0.309492; p = 0.013) (Table 5). Here, PIK3CA is linked to adenocarcinoma.