In SCLC, it can be observed that cancer gene alterations appear to be more frequent in women, the most consistent differences being observed in PTRD, CREBBP, GRM3, ATRX, NOTCH3, and PDE4DIP, while ATM appears to be altered in 5.26% of men, and no alterations were depicted in women. This evidence concerns the gene NOTCH3 and small cell lung carcinoma.