The following most altered cancer genes were LRP1B (26%), PIK3CA (24%), CDKN2A (24%), PTPRD (15%), RB1 (13%), PDE4DIP (13%), PCLO (11%), KRAS (11%), FAT1 (10%), and RELN (10%), and these results partially overlap with the most altered genes depicted in the experimental cohort. The gene discussed is RB1; the disease is cancer.