Furthermore, as partially mentioned above, even though total serum IgE levels are known to correlate with the presence of asthma or its severity, also independently of atopy [39,40], it is not fully elucidated if they mechanistically contribute to or are only a secondary epiphenomenon of asthma [36,37], possibly resulting from a polyclonal stimulation by other factors, e.g., staphylococcal enterotoxins [35]. The gene discussed is IGHE; the disease is asthma.