In fact, two ClinVar variants had at least one star with no conflicting LP interpretations and might be common founder mutations in the Middle East, associated with primary ciliary dyskinesia (DNAAF4) and 3-methylcrotonyl-CoA carboxylase 2 deficiency (|MCCC2) (Supplementary Table S2), leading to a higher incidence of such diseases in this region. Here, DNAAF4 is linked to hyperinsulinemic hypoglycemia, familial, 4.