As receptors for SRPX2, urokinase plasminogen activator receptor (uPAR) [65] and hepatocyte growth factor (HGF) [61] are known, and it was found that SRPX2 was secreted into the culture supernatant by treating oral cancer cell lines with recombinant proteins of uPAR and HGF. This evidence concerns the gene HGF and lip and oral cavity carcinoma.