OTOR and melanoma: Members of the melanoma inhibitory activity (MIA) gene family are secreted proteins that comprise MIA, MIA2, transport and Golgi organization protein 1 (TANGO), and otoraplin (OTOR) and share 34–45% amino acid homology and 47–59% cDNA sequence homology and possess a highly conserved Src homology 3 (SH3)-like domain and hydrophobic N-terminal secretory signal sequence [43].