We evaluated the relation between variant genotypes of the TLR2 rs5743708, TLR4 (rs11536889, rs4986790, rs4986791), and TLR9 (rs187084, rs352140, rs5743836) SNPs with somatic mutations (FLT3, NPM1, DNMT3A) and clinical features and overall survival of AML patients. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.