We carried out this case-control study to estimate the overall AML risk of the TLR2 rs5743708, TLR4 rs11536889, TLR4 rs4986790, TLR4 rs4986791, TLR9 rs187084, TLR9 rs352140, and TLR9 rs5743836 polymorphisms in a large group of Caucasian adult AML patients. The gene discussed is TLR4; the disease is acute myeloid leukemia.