The CSF levels of biomarkers, which are usually detected in serum, such as interleukin-6 (IL-6) as an indicator of inflammation process [8], neuron-specific enolase (NSE) [9] and S100 protein [10] as indicators of the brain cell damage, are of great interest to study different pathologies, including post-neurosurgical meningitis. Here, ENO2 is linked to infectious meningitis.