Recently, the identification of mutations in FANC genes such as FANCD1/BRCA2 [27,28], FANCJ/BRIP1 [27,29], FANCN/PALB2 [27,30], and FANCA [29,31], among CRC patients who did not harbor detectable mutations in known CRC susceptibility genes, highlights the role of FANC genes as potential CRC predisposition genes. The gene discussed is BRCA2; the disease is colorectal carcinoma.