As summarized in Table 1, among 22 FANC genes, FANCS/BRCA1 and FANCD2/BRCA2, high-risk hereditary breast-ovarian cancer syndrome susceptibility genes, are the most investigated as CRC susceptibility genes beyond its well-known predispositions [27,28,29,30,31,44,73,82,83,84,85,86,87,88,89]. This evidence concerns the gene FANCD2 and colorectal carcinoma.