A Mendelian randomization study also showed that the C allele in rs2228145 was associated with a lower risk of coronary heart disease [12], but a meta-analysis of three GWA scans with 4107 type 2 diabetes cases and 5187 controls in Caucasians found no evidence that IL6R variants were associated with type 2 diabetes [13]. The gene discussed is IL6R; the disease is coronary artery disorder.