miR-16-5p was found to target multiple binding sites across coronavirus species [173,244], binds to 15 binding sites on the SARS-CoV-2 genome, is abundant in the alveolar A549 cells [173], regulate the COVID-19–ACE2 interaction networks [243], and downregulate the expression of IL-1β, IL-6, and TNF-α [245,246]; hence, it can be ideal choice to quell the storming cytokines of COVID-19. The gene discussed is ACE2; the disease is COVID-19.