The SV reduction in MPN patients is not only related to splanchnic vein recanalization and portal pressure normalization, but also to disease burden and inflammation reduction, as shown in the current work; an inverse relationship between CRP and splenic volume reduction was observed in the RUX group and in the HU group, and a direct relationship between splenic volume reduction and the size of thrombosis recanalization was observed in the RUX group and in the HU group. Here, CRP is linked to myeloproliferative disorder.