Overexpression of AGTR-1 directs both ligand-independent and ligand-dependent activation of NF-κB (a universal transcription factor that controls the expression of immune response genes, apoptosis and cell cycle; dysregulation of NF-κB causes inflammation, autoimmune diseases, as well as the development of viral infections and cancer), mediated by a signaling pathway, the initiation of which causes internal reactions of cancer cells, including proliferation, migration, and invasion. The gene discussed is NFKB1; the disease is cancer.