Specific IgE to Malassezia sympodialis allergen Mala s 11, a Mn superoxide dismutase, is correlated with the severity of atopic dermatitis, supposedly by inducing the release of several pro-inflammatory cytokines, such as interleukin (IL)-6, IL-8, IL- 12p70 and TNF-α, by dendritic cells [70]. This evidence concerns the gene IGHE and atopic eczema.